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KMID : 1123920120260040506
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 4 p.506 ~ p.510
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Effect of Drynariae Rhizoma in RANKL-induced Osteoclast Differentiation
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Kwack Seong-Cheoul
Moon Seo-Young
Kwak Han-Bok
Jeon Byung-Hoon
Oh Jae-Min
Choi Min-Kyu
Kim Jeong-Joong
Jang Sung-Jo
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Abstract
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Bone homeostasis is regulated by the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoporosis, rheumatoid arthritis and periodontal disease are related with up-regulated osteoclast formation and its activity. Gol-Swae-Bo(Drynariae Rhizoma) is widely used on skeletal disease. In this study, we sought to examine the effect of Drynariae Rhizoma in RANKL-induced osteoclast differentiation. The extract of Drynariae Rhizoma inhibited RANKL-induced osteoclast differentiation in a dose dependent manner without cytotoxicity. receptor activator of nuclear factor-kB ligand(RANKL) mediated IkB degradation in bone marrow macrophages(BMMs). However, the extract of Drynariae Rhizoma inhibited RANKL induced IkB degradation in BMMs. And mRNA expression of OSCAR, TRAP, c-Fos and NFATc1 was suppressed by the extract of Drynariae Rhizoma. Moreover, the extract of Drynariae Rhizoma inhibited the protein expression of NFATc1 and c-Fos induced by RANKL. After all the analysis, these results suggest that Drynariae Rhizoma may be good candidate of medicine in the treatment of bone-related disease.
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KEYWORD
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Drynariae Rhizoma, Osteoclast, RANKL, Osteoporosis
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